Curriculum Vitae

                     

Dr. Shiva Khezri

 

Assistant professor in Department of Biology            

Faculty of Science

Urmia University

Urmia, Iran

E.mail: sh.khezri@urmia.ac.ir

 

    PERSONAL DETAILS

 

 

·        Birth place: Salmas, Iran

·        Present citizenship: Iranian

 

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     EDUCATION

 

·        1998-2002 B.Sc. in Biology, Faculty of Sciences, Urmia University, Urmia, Iran.

 

 ·        2002-2005    M.Sc. in physiology, Faculty of Sciences, Tehran University, Tehran, Iran.

  

 

 

·      2006-2011       Ph.D in medical physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

 

 

 

 

     THESIS AND DESSERTATION

  

·        M.Sc.: Evaluation of chronotropic properties of mouse embryonic stem cells derived cardiomyocytes after fibroblast growth factor treatment.

 

·        Ph.D.: Studying the effect of Nogo signaling inhibition on the symptoms and endogenous neural stem cells migration in EAE model of multiple sclerosis in C57BL/6 mice.

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    RESEARCH INTERESTS

 

·        Adult neural stem cell behavior including their proliferation, migration, survival, and differentiation in response to CNS injuries.

·        Methods involved in manipulation in vivo with less invasive instrument.

·        Developmental neurobiology and the repair capacity of adult brain,

·        Degeneration and regeneration in CNS.

·        Neurodegenerative diseases such as Multiple sclerosis.

·        Remyelination and Demyelination,

·        Oligodendrocyte apoptosis, proliferation, differentioation.

·        cell culture.

·        RNAi-mediated gene silencing in vitro and in vivo.

·        Differentiation of embryonic stem cells to cardiomyocytes.

 

 

   MEMBERSHIP OF SCIENTIFIC SOCIETIES: 

·         International Brain Research Organization (IBRO)

·         Iranian Society of Physiology and Pharmacology

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     PUBLICATIONS

 

·        Khezri S, Javan M, Goudarzvand M, Baharvand H, Semnanian S.   Dibutyryl-cyclic-AMP inhibitsthe progression of experimental autoimmune encephalomyelitis and potentiates recruitment of endogenous neural stem cells. Journal of molecular neuroscience. 2013 Jan 19. [Epub ahead of print]

 

·        Khezri S, Javan M, Baharvand H, Semnanian H. Reaction of subventricular zone stem cells to the induction of experimental autoimmue encephalomyelitis in mouse. Physiology and Pharmacology. 2011; 15 (2), 229-240.

 

·        Khezri S, Javan M, Baharvand H, Semnanian S. The Effect of Systemic Administration of dbcAMP on Neural Stem Cells Migration in EAE Model of Multiple Sclerosis. Journal of Sabzevar University of Medical Sciences. 2011; 18 (3), 179-187.

 

·        Khezri SValojerdi MRSepehri HBaharvand H . Effect of basic fibroblast growth factor on cardiomyocyte differentiation from mouse embryonic stem cells. Saudi Med J. 2007; 28(2):181-6.

 

·        Khezri SValojerdi MRSepehri HBaharvand H. The Effect of Basic Fibroblast Growth Factor on Differentiation of Mouse Embryonic Stem Cells into Cardiomyocytes. Cell Journal (Yakhteh). 2005; 7 (3): 172- 177.

 

·        Khezri SValojerdi MRSepehri HBaharvand H . Evaluation of chronotropic properties of mouse embryonic stem cells derived cardiomyocytes after fibroblast growth factor treatment. JOURNAL OF IRANIAN ANATOMICAL SCIENCES. 2004; 2(1):11-17.

 

 

 

     ABSTRACTS IN CONGRESS

 

·        2005   Khezri SSepehri HBaharvand HValojerdi MRThe effect of fibroblast growth factor on differentiation of mouse embryonic stem cells- derived cardiomyocytes. 21st Annual Meeting of the European Society of Human Reproduction and Embryology, Copenhagen, Denmark.

 

·        2005   Khezri SValojerdi MRSepehri HBaharvand HEvaluation of chronotropic properties of cardiomyocytes differentiated from mouse embryonic stem cells after fibroblast growth factor  treatment.13th World Congress on “IN VITRO FERTILIZATION” (Assisted reproduction and genetics) Istanbul, Turkey.

 

·        2007   Khezri SValojerdi MRSepehri HBaharvand HThe effect of bFGf on gene expression and pharmacological properties of cardiomyocytes derived from embryonic stem cells. 18th Iranian congress of Physiology and pharmacology, Mashhad University, Mashhad, Iran.

 

·        2009   Khezri S, Javan M, Baharvand H, Semnanian S. siRNA-Mediated Knock Down of NgR for Regeneration Induction in C57BL/6 Mouse. 19th Iranian congress of  Physiology and pharmacology, Shahid Beheshti University, Tehran, Iran.

 

·        2010   Khezri S, Javan M, Baharvand H, Semnanian SStudying the effect of dbcAMP signaling on migration of BrdU positive cells in EAE model of multiple sclerosis in mice. 6th International Heinrich F.C. Behr-Symposium o Stem cells and Cancer, DKFZ Heidelberg, Germany.

 

·        2011 Khezri S, Javan M, Baharvand H, Semnanian S. Studying the effect of cyclic AMP on the symptoms of EAE model of multiple sclerosis and myelin repair by neural stem cells in mice. 8th IBRO World Congress of Neuroscience, Florence, Italy.

 

·        2011 Javan M, Khezri S, Baharvand H, Semnanian S Nogo receptor knockdown in EAE-mice potentiates myelin repair by mobilizing endogenousneural stem cells. 8th IBRO World Congress of Neuroscience, Florence, Italy.

 

·        2011  Khezri S, Javan M, Baharvand H, Semnanian S. Nogo receptor knockdown in EAE-induced mice. 20th Iranian congress of Physiology and pharmacology, Hamedan University, Hamedan, Iran.

 

·        2012 kiamarsian N, khezri S, rahmani F, dasht bozorgi N, Molecular study of green tea catechin effect on remyelination of rat hippocampal formation following lysolecithin- induced demyelination, Basic and clinical neuroscience, Tehran university of medical science, Tehran, Iran.

 

·        2012  Dasht bozorgi N, khezri S, Rahmani F, kiamarsian N. Caffeine stimulates remyelination in rat hippocampus following demyelination induction by lysolecithin. Basic and clinical neuroscience, Tehran university of medical science, Tehran, Iran.

 

·        2012 Javan M, Pourabdolhossein F, Khezri S, Demeniex B. Knocking down of myelin inhibitory proteins receptor potentiates remyelination and attenuates the symptoms in EAE-induced mice. Basic and clinical neuroscience, Tehran university of medical science, Tehran, Iran.

 

·        2012 kiamarsian N, khezri S, Ilkhanipour M, Dasht bozorgi. Effect of catechin on remyelination of rat hippocampus and improvement of spatial memory following lysolecithin-induced demyelination

17th Naional & 5th International biology conference, Kerman university, Kerman.

 

·        2012 Dasht bozorgi N, khezri S, Ilkhanipour M, kiamarsian N. Study the effect of caffeine on spatial learning and hippocampus remyelination after demyelination induction by lysolecithin in rat.17th Naional & 5th International biology conference, Kerman university, Kerman.                   

 

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       SEMINARS

 

·        2006 ”  Multiple Sclerosis and Cell Therapy ”     Tarbiat Modares University, Tehran-Iran.

·        2006   On” Fatigue in MS”,Tarbiat Modares,University of ,Tehran.

 

·        2006   On”Rehabilitation Medicine”,Tarbiat Modares,University of ,Tehran.

 

·        2006 ”  Possible involvement of endogenous Adult Neural Stem Cell as a physiological capacity in remyelination of lysolecethin-induced demylination in mice optic nerve and chiasma”,     Tarbiat Modares University, Tehran-Iran.

 

·        2006  ” Micro RNAs: Genomics, Biogenesis, Mechanism and function”, Tarbiat Modares University, Tehran-Iran

 

·        2007   On”Origin of adult neural stem cell in adult CNS from SVZ” ,Tarbiat Modares University of ,Tehran.

 

·        2007  ” Functional anatomy of siRNA”, Tarbiat Modares University, Tehran-Iran.

 

·        2007    ”   Multiple Sclerosis: A two stage disease”, Tarbiat Modares University, Tehran-Iran.

 

·        2007  ”   Why does remyelination fail in multiple sclerosis? ”, Tarbiat Modares University, Tehran-Iran.

 

·        2008   On”Cell therapy in Multiple Sclerosis and alzheimer”, Tarbiat Modares University of, Tehran.

 

·        2008    ” RNAi and siRNA”, Tarbiat Modares University, Tehran-Iran.

 

·        2008    ” MS and Nogo receptor”, Tarbiat Modares University, Tehran-Iran.

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       RESEARCH AND PROJECTS

 

·        2003 Molecularbiology (Western blot, RT-PCR, Immunohistochemistry…)

 

·        2003   Cell culture

 

·        2003   Differential of embryonic stem cells to cardiomyocytes

 

·        2006 Endogenous neural stem cell migration in response to demyelinating insult

 

·        2007  Gene expression assessment of NogoA in oligodendrocyte cell in response to demyelinating insult of endogenous Mesenchymal stem cells

 

·        2008   Study of protective effect of VitE and VitD on neural stem cells in hippocampus in response to demyelinating insult (theoretical studies)

 

·        2008   EAE induction as a model of MS

 

·        2009   Application and design of siRNA in migration of endogenus neural stem cell (theoretical studies)

 

·        2010   Autoghagy induction in SH-S5Y5 cells

 

·        2010   RNAi-mediated gene silencing in vitro

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          COURSES TAUGHT:

·        General Physiology (Biology student) in Urmia university, Urmia, Iran.   

·         Membrane Physiology (M.Sc Biology student) in Urmia university, Urmia, Iran.

·         Circulation Physiology (M.Sc Biology student) in Urmia university, Urmia, Iran.

·         Reproductive Physiology (M.Sc Biology student) in Urmia university, Urmia, Iran.

·         Central nervous system Physiology (M.Sc Biology student) in Urmia university, Urmia, Iran.

 

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     PRESENTED WORKSHOP

 

  •   2012     Presentation of Western blot workshop in Physiology Department, Tarbiat Modares University.

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     RESEARCH PERIOD 

  •        2010   Visiting researcher at Neurology department, Goettingen University, Germany, for a joint research on Comparison of 2 different siRNAs against Ulk1 and Atg7 in SH-SY5Y-cells using Western Blot for P62 and LC3 with the group of Dr Paul Lingor, April - December 2010.

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    GRANT

 

·        Grant from Multiple Sclerosis International Federation (MSIF) to cover my visiting research to Neurology department – Germany 2010.

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    Prizes

 

 

·        Professor Dr Giti´s Prize (Gold coin and certification) from 20th Iranian congress of Physiology and pharmacology as the best researcher. Professor Dr Giti´s Prize is awarded by Iranian Society of Physiology and pharmacology for outstanding scientific achievements.

 

 

 

   TECHNICAL EXPERIENCES

 

·        Adult mouse neural stem cells : Migration study in fixed brain dissections

·        Immunohistochemistry, single and double labeling

·        Generating Animal Model of MS (e.g. EAE) disease

·        Histochemistry, Counterstaining with Luxol fast Blue (a myelin dye) and Cresyl Fast Violet

·        Western blot analysis of protein expression

·        Basic techniques in molecular biology, such as RT-PCR

·        Behavioral tests, such as tail flick test and formalin test for study of pain

·        Animal surgeries and application of steriotaxic instrument

·        In vivo and in vitro siRNA transfection through non-viral methods

·        Intrathecal catheterization into Spinal Cord

·        Differentiation of embryonic stem cells to cardiomyocytes in vitro

·       Autoghagy induction in SH-S5Y5 cells

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    EXTRACURRICULAR EDUCATIONAL COURSES

 

·        2005    ”Method of research” ,Tarbiat Modares University, Tehran

·        2006   ”Scientific Ethics”,Tarbiat Modares University,Tehran

·       2006 ”Scientific Writing and Communication”,Tarbiat Modares University,Tehran.

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    LANGUAGES

 

·        Azari (Native), Persian (Fluent), English (Good)

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   PERSONAL INTEREST

 

·        Mountain climbing, Ping pong, Poem, Literature.

 

 

   COMPUTER SKILL

 

·        Microsoft Office: Word, Excel, PowerPoint.

·        Operating System: Windows, Mac

·        Statistical softwares: SPSS, GraghPad Prism.

 

·        Biological softwares: Gene Runner, Image j, Scion